CEACAM1 Mouse Monoclonal Antibody [Clone ID: 8G5]

Specifications

Product Data
Clone Name	8G5
Applications	ELISA, FC, IF, IHC
Recommend Dilution	Flow Cytometry: 1.2 μg/106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Immunofluorescence. Immunohistochemistry on Cryosections: 10 μg/ml.
Reactivity	Human, Mammalian
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunisation with cDNA encoding the extracellular region of Human CEACAM1-A2. Based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity	This antibody recognizes Human CEACAM1 (biliary glycoprotein I, BGP/CD66a). This antibody detects complete native protein expressed on transfected cells.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: None
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	carcinoembryonic antigen related cell adhesion molecule 1
Database Link	Entrez Gene 634 Human UniProt ID P13688
Background	CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family (1,2). It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells (3). The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (4). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
Synonyms	BGP, BGP1, Biliary glycoprotein 1
Reference Data

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