Prostate Specific Antigen (KLK3) Mouse Monoclonal Antibody [Clone ID: LT-3D2]

Specifications

Product Data
Clone Name	LT-3D2
Applications	ELISA, FC, WB
Recommend Dilution	Flow cytometry: 1.2 µg/106 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunisation with cDNA encoding Human PSA
Specificity	Recognizes Human PSA (glandular Kallikrein 3). Other species not tested.
Formulation	Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	kallikrein related peptidase 3
Database Link	Entrez Gene 354 Human UniProt ID P07288
Background	Prostate specific antigen (PSA) belongs to the kallikrein gene family. It is a single-chain glycoprotein with a molecular mass of about 33 kD which is produced by prostate epithelial cells. It is secreted in the seminal plasma and is responsible for liquefaction of the seminal coagulum (1,2). PSA is present in small quantities in the serum of healthy males, and is often elevated in the presence of prostate cancer and in other prostate disorders. It is one of the most useful tumour markers because of its tissue specificity. It is thus widely used for screening, diagnosis, and monitoring patients with prostate cancer (3).
Synonyms	Prostate-specific antigen, Semenogelase, Gamma-seminoprotein, P-30 antigen
Note	SDS-PAGE analysis of LT-3D2: The antibody was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-Page (Figure.2).
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Pathways in cancer, Prostate cancer

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