IL13 receptor alpha 1 (IL13RA1) (Extracell. Dom.) Mouse Monoclonal Antibody [Clone ID: GM1E7]

Specifications

Product Data
Clone Name	GM1E7
Applications	ELISA, FC, IF
Recommend Dilution	Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 µg/106 cells. Immunofluorescence: 1 µg/106 cells. Specific inhibition of IL-13-dependent proliferation of TF-1 cells by GM-1E7 (See Figure.3).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunization with cDNA encoding Human IL13-R alpha 1 (extracellular domain). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity	Recognizes IL13 Receptor (IL13-R).
Formulation	Phosphate buffered saline, pH 7.2 without preservatives State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 13 receptor subunit alpha 1
Database Link	Entrez Gene 3597 Human UniProt ID P78552
Background	Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Ra1 together with IL-4Ra forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation
Synonyms	Interleukin-13 receptor alpha-1 chain, IL-13R-alpha-1, IL-13RA-1, IL13R, IL13RA, IL13 receptor alpha, CT19
Note	SDS-PAGE analysis: The antibody was purified by Protein G Affinity Chromatography from cell culture supernatants and verified by SDS-Page (Figure.4).
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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