GFAP Mouse Monoclonal Antibody [Clone ID: 6F2]

Specifications

Product Data
Clone Name	6F2
Applications	IHC, WB
Recommend Dilution	Immunoblotting. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections. Recommended Dilutions: 1/25–1/200 for Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1/100–1/1000 for Immunoblotting applications. Recommended Positive Control: Brain.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Glial Fibrillary Acidic Protein from Human brain.
Specificity	This antibody 6F2 reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freeze-thaw cycles.
Gene Name	glial fibrillary acidic protein
Database Link	Entrez Gene 2670 Human UniProt ID P14136
Background	GFAP (55 kD) is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer's disease, epilepsy and multiple sclerosis. In the peripheral nervous system GFAP is expressed by Schwann cells. Upon differentiation, myelin forming Schwann cells down-regulate GFAP, whereas in non-myelin forming Schwann cells GFAP persists into adulthood.
Synonyms	Glial Fibrillary Acidic Protein
Reference Data

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