MCP3 (CCL7) Mouse Monoclonal Antibody [Clone ID: 113]

Specifications

Product Data
Clone Name	113
Applications	ELISA
Recommend Dilution	ELISA: This MCP3 antibody HRP-conjugated can be used as a Tracer/Detection Antibody in Sandwich ELISA applications for human MCP-3 detection in combination with a Capture antibody (Cat#DM2039) Suggested Capture Coating Dose: 3 µg/well Substrate: TMB
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Recombinant Human Monocyte Chemotactic Protein-3 (MCP-3).
Specificity	Reactive with natural and recombinant human MCP-3. Does not show any cross reaction with other Human Cytokines or growth factors tested such as IL1 beta, IL-8, MCAF, SAA and EGF
Formulation	0.01M PBS, pH 7.0 ± 0.1 in 50% Glycerol and 0.01% Thimerosal as a bacteriostat Label: HRP State: Liquid purified IgG fraction Label: Horseradish Peroxidase
Purification	Affinity Chromatography on Protein G.
Conjugation	HRP
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine ligand 7
Database Link	Entrez Gene 6354 Human UniProt ID P80098
Background	Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.
Synonyms	Small-inducible cytokine A7, CCL-7, MCP-3, C-C motif chemokine 7, SCYA6, SCYA7, NC28
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

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