p57 Kip2 (CDKN1C) Mouse Monoclonal Antibody [Clone ID: 57P06]
CAT#: DM291
p57 Kip2 (CDKN1C) mouse monoclonal antibody, clone 57P06, Purified
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CNY 11,906.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | 57P06 |
Applications | IHC, IP |
Recommend Dilution | Immunuprecipitation (Native). Immunohistochemistry on Paraffin Embedded Sections: 1/25-1/50 in an ABC method 30-60 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Colon carcinoma. |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | BALB/C mice were injected with mouse recombinant p57Kip2protein. |
Specificity | This antibody is specific to a protein of 57 kD known as p57Kip2 a cell cycle regulatory mitotic inhibitor. It does not cross react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and is negative regulator of cell proliferation. |
Formulation | State: Purified State: Liquid purified IgG fraction containing Sodium Azide as preservative. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | cyclin-dependent kinase inhibitor 1C |
Database Link | |
Background | p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms. |
Synonyms | p57KIP2 |
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