Herpes Virus Type 8 / HHV8 Rat Monoclonal Antibody [Clone ID: LN53]

Specifications

Product Data
Clone Name	LN53
Applications	IHC
Recommend Dilution	Immunohistochemistry: Use at 1/25-1/50 dilution in an ABC method (30 to 60 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Kaposi's sarcoma.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.
Specificity	This antibody stains with ORF-73 of Human Herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi's sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. Cellular Localization: Nuclear.
Formulation	State: Purified State: Liquid purified Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Background	HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
Synonyms	HHV-8, KHSV
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.