GFAP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: This antibody may be diluted to a titer of 1/50-1/250 using a polymer detection system (30 minutes at Room Temperature). Heat induced antigen retreiveal with 10 mM citrate buffer, pH 6.0 is recommended. Recommended Positive Control: Brain.
Reactivity	Bovine, Chicken, Feline, Guinea Pig, Hamster, Human, Kangaroo, Monkey, Mouse, Rat, Sheep
Host	Rabbit
Clonality	Polyclonal
Immunogen	GFAP isolated from Cow spinal cord.
Specificity	This antibody reacts with GFAP. In the central nervous system, this antibody stains Astrocytes and some groups of Ependymal cells. However, in the peripheral nervous system, it stains Schwann cells, satellite cells and enteric glial cells. Cellular Localization:Cytoplasmic.
Formulation	State: Purified State: Liquid purified Ig fraction Preservative: < 0.1% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	glial fibrillary acidic protein
Database Link	Entrez Gene 2670 Human UniProt ID P14136
Background	Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.
Synonyms	Glial Fibrillary Acidic Protein
Reference Data

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