Granzyme B (GZMB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide from the N-terminus of human Granzyme B.
Formulation	10 mM Citrate Buffer, pH 6.0 containing Sodium Azide as preservative.
Purification	Liquid purified Ig fraction. Purified
Conjugation	Unconjugated
Predicted Protein Size	~25.5 kDa
Gene Name	granzyme B
Database Link	NP_004122 Entrez Gene 14939 MouseEntrez Gene 171528 RatEntrez Gene 3002 Human UniProt ID P10144
Background	Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzymes B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTLs or NK cells.
Synonyms	C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; Fragmentin-2; Granzyme-2; GRB; HLP; SECT
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Allograft rejection, Autoimmune thyroid disease, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus

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