AMACR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABC method (30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Prostate carcinoma.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic human AMACR peptide.
Specificity	Reacts to P504S Alpha-Methylacyl-CoA Racemace. Cellular Localization: Cytoplasmic.
Formulation	< 0.1% Sodium Azide State: Purified State: Liquid purified Ig fraction
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	alpha-methylacyl-CoA racemase
Database Link	Entrez Gene 23600 Human UniProt ID Q9UHK6
Background	P504S (AMARC) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
Synonyms	Alpha-methylacyl-CoA racemase, P504S
Reference Data

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