RNF2 (189-201) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/5,000-1/25,000. Western blot: 1/500-1/2,000. Expect a band approximately 38 kDa in size corresponding to RING1B by in the appropriate cell lysate or extract. Immunofluorescence. Immunohistochemistry on Paraffin Sections (2.5 µg/ml).
Reactivity	Bovine, Canine, Chimpanzee, Chicken, Frog, Human, Mouse, Orang-Utan, Rat, Zebrafish
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding aa 189-201 of Human RING1B protein
Specificity	This antibody detects RING1B.
Formulation	0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2 as buffer and 0.01% (w/v) Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store vial at -20°C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
Gene Name	ring finger protein 2
Database Link	Entrez Gene 6045 Human UniProt ID Q99496
Background	RING1B (also known as BAP1, DING, Polycomb-M33 interacting protein Ring1B, Ring finger protein 1b, Ring finger protein 2 and RNF2) is one of the PcG proteins. The polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), a ubiquitin-conjugating enzyme that possesses ubiquitin ligase activity.
Synonyms	RING finger protein 2, BAP1, BAP-1, DING, HIPI3, RING1B
Note	336 aa, predicted MW 37.6 kDa Protocol: a b c d
Reference Data

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