Cd3e Rat Monoclonal Antibody [Clone ID: KT3]

CAT#: SM003R

Cd3e rat monoclonal antibody, clone KT3, PE



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CNY 6,369.00


货期*
4周

规格
    • 100 Tests

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Specifications

Product Data
Clone Name KT3
Applications FC
Recommend Dilution Flow Cytometry: Use 10 µl of neat antibody to label 106 cells. For optimal staining incubations should be performed at room temperature; The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Reactivity Mouse
Host Rat
Clonality Monoclonal
Immunogen Spleen cells from immunised SD rats were fused with cells of the NSO mouse myeloma cell line.
Specificity This antibody recognises the CD3 antigen which is expressed by mature T cells.
Formulation PBS, pH 7.4
Label: PE
State: Lyophilized purified IgG fraction
Stabilizer: 5% Sucrose, 1% BSA
Preservative: 0.09% Sodium Azide
Label: R. Phycoerythrin (RPE)
Reconstitution Method Restore with 1.0 ml distilled water.
Purification Affinity Chromatography on Protein A from tissue culture supernatant.
Conjugation PE
Storage Condition Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Gene Name CD3 antigen, epsilon polypeptide
Background Cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Synonyms T3/Leu-4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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