CD14 Mouse Monoclonal Antibody [Clone ID: Tük4]

Specifications

Product Data
Clone Name	Tük4
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of Neat-1/10 diluted antibody to label 106 cells or 100 µl whole blood.
Reactivity	Bovine, Canine, Feline, Goat, Human, Mink, Monkey, Porcine, Rabbit, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	CD14 Human
Specificity	This antibody recognises the CD14 cell surface antigen, expressed strongly by most peripheral blood monocytes and weakly on granulocytes. Clone TÜK4 has been shown to block SDF-induced chemotaxis of U937 cells in a dose-dependent manner. The use of SM1066LE is recommended for this purpose.
Formulation	PBS Label: PE State: Lyophilized purified IgG fraction Stabilizer: 1% BSA, 5% Sucrose Preservative: 0.09% Sodium Azide Label: R. Phycoerythrin
Reconstitution Method	Restore with 1 ml distilled water
Purification	Affinity Chromatography on Protein G
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD14 molecule
Database Link	Entrez Gene 929 Human UniProt ID P08571
Background	CD14 is a single copy gene encoding 2 protein forms: a 50 to 55 kDa glycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liver derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes.
Synonyms	CD14
Reference Data

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