CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: 3G8]

CAT#: SM1072LE

CD16 (FCGR3A) mouse monoclonal antibody, clone 3G8, Low Endotoxin



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CNY 3,140.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name 3G8
Applications FC, FN, IHC, IP
Recommend Dilution
Flow cytometry: 6 μg/ml.
Immunoprecipitation.
Immunohistochemistry (frozen sections): acetone fixation.
Functional application: In vitro Stimulation of NK cell proliferation, blocking of IgG binding and phagocytosis, inhibition of cytotoxic activity, in vivo NK cell depletion.
Reactivity Human, Primate
Host Mouse
Clonality Monoclonal
Immunogen Human neutrophils
Specificity This antibody recognizes CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65 kDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48 kDa; mainly expressed on neutrophils).
Formulation Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
State: Low Endotoxin
State: Liquid Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name Fc fragment of IgG receptor IIIa
Background CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms – FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
Synonyms FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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