CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: 3G8]
CAT#: SM1072LE
CD16 (FCGR3A) mouse monoclonal antibody, clone 3G8, Low Endotoxin
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CNY 3,140.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 3G8 |
Applications | FC, FN, IHC, IP |
Recommend Dilution | Flow cytometry: 6 μg/ml.
Immunoprecipitation.
Immunohistochemistry (frozen sections): acetone fixation.
Functional application: In vitro Stimulation of NK cell proliferation, blocking of IgG binding and phagocytosis, inhibition of cytotoxic activity, in vivo NK cell depletion. |
Reactivity | Human, Primate |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human neutrophils |
Specificity | This antibody recognizes CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65 kDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48 kDa; mainly expressed on neutrophils). |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | Fc fragment of IgG receptor IIIa |
Database Link | |
Background | CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms – FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. |
Synonyms | FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2 |
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