CD59 Mouse Monoclonal Antibody [Clone ID: MEM-43]

Specifications

Product Data
Clone Name	MEM-43
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 20 µl reagent / 100 µl of whole blood or 10e6 cells in a suspension.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Thymocytes and T lymphocytes
Specificity	SM1145F reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
Formulation	PBS containing 15 mM Sodium Azide and 0.2% (w/v) high-grade protease free BSA as a stabilizing agent Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated
Conjugation	FITC
Storage Condition	Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD59 molecule
Database Link	Entrez Gene 966 Human UniProt ID P13987
Background	CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Synonyms	MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20
Reference Data

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