CD79A Mouse Monoclonal Antibody [Clone ID: ZL7-4]

Specifications

Product Data
Clone Name	ZL7-4
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of neat antibody to label 1x10e6 cells in 100µl. We recommend incubation times of at least 30 minutes with this antibody.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	IgM complex isolated from Daudi cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity	This antibody reacts with CD79a positive cells by flow cytometry. This clone has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma in flow cytometric assays.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. Label: FITC State: Liquid purified IgG fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD79a molecule
Database Link	Entrez Gene 973 Human UniProt ID P11912
Background	A disulfide-linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, is non-covalently associated with membrane bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.
Synonyms	IGA, MB1, B-Cell marker
Reference Data

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