C5R1 (C5AR1) (N-term) Mouse Monoclonal Antibody [Clone ID: S5/1]

Specifications

Product Data
Clone Name	S5/1
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human, Bovine, Rabbit, Ferret
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
Specificity	This antibody recognizes the CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
Formulation	Phosphate buffered saline (PBS) Label: PE State: Liquid purified Ig fraction Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	complement component 5a receptor 1
Database Link	Entrez Gene 728 Human UniProt ID P21730
Background	CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.
Synonyms	C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1
Reference Data

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