HLAB (HLA-B) Mouse Monoclonal Antibody [Clone ID: BB7.1]

Specifications

Product Data
Clone Name	BB7.1
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50 diluted antibody to label 10e6 cells or 100 µl of whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Papain solubilized HLA-B7 antigen.
Specificity	This antibody recognises the HLA-B7 antigen and does not cross-react with HLA-B27 or other related antigens. It can be used to distinguish true HLA-B27 positives from false HLA-B27 positives (i.e. HLA-B7 positive) in the investigation of diseases such as ankylosing spondylitis and anterior uveitis.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	major histocompatibility complex, class I, B
Database Link	Entrez Gene 3106 Human UniProt ID P01889
Background	HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described. Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing.
Synonyms	HLAB, MHC class I antigen B7
Reference Data

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