Myelin Basic Protein (MBP) (84-89) Mouse Monoclonal Antibody [Clone ID: 22]

Specifications

Product Data
Clone Name	22
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. Recommended Positive Control: Brain. Has been reported to work in Western blotting.
Reactivity	Human, Mammalian
Host	Mouse
Clonality	Monoclonal
Immunogen	Human myelin basic protein. Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
Specificity	This antibody recognises an epitope of Human myelin basic protein between amino acids 84-89. Reacts with MBP from most species.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	myelin basic protein
Database Link	Entrez Gene 4155 Human UniProt ID P02686
Background	The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
Synonyms	MBP
Reference Data

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