CD147 (BSG) Mouse Monoclonal Antibody [Clone ID: MEM-M6/1]
CAT#: SM1602PS
CD147 (BSG) mouse monoclonal antibody, clone MEM-M6/1, Purified
Size: 200 ug
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CNY 3,280.00
货期*
5周
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Clone Name | MEM-M6/1 |
Applications | FC, IHC, IP, WB |
Recommend Dilution | Flow Cytometry: 10 μg/ml. Immunoprecipitation. Western blot (under non-reducing conditions): 1 µg/ml. Immunohistochemistry on Paraffin Sections: 10 μg/ml. Positive tissue: testis. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of Human IgG1 (CD147Rg is secreted by transfectants as a dimer) |
Specificity | The antibody recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells. |
Formulation | PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | basigin (Ok blood group) |
Database Link | |
Background | CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function. |
Synonyms | Basigin, BSG, EMMPRIN, TCSF |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density
,Koch C, Staffler G, H|ttinger R, Hilgert I, Prager E, Cern} J, Steinlein P, Majdic O, Horejsm V, Stockinger H,
Int. Immunol.
,PubMed ID 10330283
[BSG]
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