MADCAM1 Mouse Monoclonal Antibody [Clone ID: CA102.2C1]

Specifications

Product Data
Clone Name	CA102.2C1
Applications	ELISA, FN, WB
Recommend Dilution	ELISA. Western blotting. Functional assay.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Bacterially expressed human MAdCAM-1.
Specificity	This antibody recognises MAdCAM-1 (mucosal addressin cell adhesion molecule -1), a 40kD protein expressed by vascular endothelium. Clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro.
Formulation	PBS State: Azide Free State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	mucosal vascular addressin cell adhesion molecule 1
Database Link	Entrez Gene 8174 Human UniProt ID Q13477
Background	MAdCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM1 (alpha4 beta7), L selectin, and VLA4 (alpha4 beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full length nature of some variants has not been determined.
Synonyms	hMAdCAM-1, MAdCAM-1, Mucosal addressin cell adhesion molecule 1
Reference Data

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