Anpep Rat Monoclonal Antibody [Clone ID: R3-63]

Specifications

Product Data
Clone Name	R3-63
Applications	FC
Recommend Dilution	Flow Cytometry Neat
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse intestinal APN
Specificity	MCA2183PE recognises mouse aminopeptidase N (APN), a cell surface protein homologous with human CD13. In the mouse, CD13 is a non-covalently linked homodimer of approximately 150kD subunits expressed by a variety of cells including monocytes, macrophages, dendritic cell and veiled cells. Clone R3-63 has been reported to block mouse APN enzyme activity (1). Serotec recommend the use of MCA2183XZ for this purpose.
Formulation	Phosphate buffered saline pH7.4 0.09% Sodium Azide, 1% Bovine Serum Albumin, Label: PE State: Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
Reconstitution Method	Reconstitute in 0.25 ml disilled water
Concentration	lot specific
Purification	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Conjugation	PE
Storage Condition	Prior to reconstitution store at +4°C. Following reconstitution store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. 12 months from date of reconstitution.
Gene Name	alanyl (membrane) aminopeptidase
Database Link	Entrez Gene 16790 Mouse UniProt ID P97449
Background	CD13 also known as Aminopeptidase N is a zinc dependent exopeptidase which cleaves amino acids from the N termini of target proteins including neuropeptides and cytokines. CD13 is expressed on all cells of the myeloid lineage as well as epithelial cells of the intestine, placenta, liver and kidney. CD13 is upregulated in a number of tumour types including lung, melanoma, thyroid and hepatocarcinoma and has been shown to correlate with poor prognosis. CD13 is a crucial molecule in tumour angiogenesis. CD13 is also the receptor for viruses from the coronavirus family.
Synonyms	Aminopeptidase N, ANPEP, APN, PEPN
Reference Data

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