CD226 Mouse Monoclonal Antibody [Clone ID: DX11]

Specifications

Product Data
Clone Name	DX11
Applications	FC
Recommend Dilution	Flow Cytometry: 1/10 - 1/20; Use 10µl of the suggested working dilution to label 1 x 10e6 cells in 100µl.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human cytotoxic T lymphocyte clone. Spleen cells from immunised BALB/c mouse were fused with cells of the Sp2/0 myeloma cell line.
Specificity	This antibody recognises CD226. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells. We recommend the use of SM2023A for funtional studies.
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide and 1.0% Bovine Serum Albumin Label: FITC State: Liquid purified IgG Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Gene Name	CD226 molecule
Database Link	Entrez Gene 10666 Human UniProt ID Q15762
Background	CD226 is a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.
Synonyms	DNAX accessory molecule 1, DNAM-1
Reference Data

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