CD226 Mouse Monoclonal Antibody [Clone ID: DX11]

Specifications

Product Data
Clone Name	DX11
Applications	FC, IP
Recommend Dilution	Flow Cytometry: 1/25 - 1/100; Use 10µl of the suggested working dilution to label 1 x 10e6 cells in 100µl. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human cytotoxic T lymphocyte clone. Spleen cells from immunised BALB/c mouse were fused with cells of the Sp2/0 myeloma cell line.
Specificity	This antibody recognises CD226. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells. We recommend the use of SM2023A for funtional studies.
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide State: Aff - Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD226 molecule
Database Link	Entrez Gene 10666 Human UniProt ID Q15762
Background	CD226 is a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.
Synonyms	DNAX accessory molecule 1, DNAM-1
Reference Data

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