Integrin alpha 4 (ITGA4) Mouse Monoclonal Antibody [Clone ID: HP2/1]

CAT#: SM2198PS

Integrin alpha 4 (ITGA4) mouse monoclonal antibody, clone HP2/1, Purified

Size: 100 ug 200 ug



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CNY 4,499.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name HP2/1
Applications FC, IHC, IP
Recommend Dilution Flow cytometry: 1 µg/5 x 10e cells.
Immunohistochemsitry on frozen sections.
Immunoprecipitation.
Reactivity Bovine, Human, Monkey, Porcine, Rat
Host Mouse
Clonality Monoclonal
Immunogen JM leukaemia line.
Spleen cells from immunised BALB/c mice were fused with cells of the X63 Ag8.653 myeloma cell line.
Specificity This antibody recognises the 80kD alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells.
Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1.
Formulation PBS containing 0.09% Sodium Azide as preservative.
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity chromatography on Protein G
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name integrin subunit alpha 4
Background ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
Synonyms Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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