KLRC4-KLRK1 Mouse Monoclonal Antibody [Clone ID: 1D11]

Specifications

Product Data
Clone Name	1D11
Applications	FC, FN, IHC, IP
Recommend Dilution	Flow Cytometry: 1/50 - 1/200; use 10 µl of the suggested working dilution to label 106 cells in 100 µl. Immunoprecipitation. Immunohistochemistry on frozen sections. Functional assays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	NKL cells. Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
Specificity	This antibody is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6).
Formulation	PBS, pH7.4 State: Low Endotoxin State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	KLRC4-KLRK1 readthrough
Database Link	Entrez Gene 100528032 Human UniProt ID P26718
Background	CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells.
Synonyms	D12S2489E, NKG2D, NK cell receptor D
Note	Endotoxin Level: less than 0.01EU/mg
Reference Data

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