Cd2 Mouse Monoclonal Antibody [Clone ID: OX-34]

Specifications

Product Data
Clone Name	OX-34
Applications	FC, IHC, IP
Recommend Dilution	Flow cytometry: 1/50, use 10 µl of the suggested working dilution to label 106 cells in 100µl. Immunoprecipitation. Immunohistochemistry on frozen sections and paraffin sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Activated rat T helper cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity	This antibody recognises the CD2 cell surface antigen, a 50-54kD glycoprotein expressed by thymocytes and mature T cells.
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Cd2 molecule
Database Link	Entrez Gene 497761 Rat UniProt ID P08921
Background	CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.
Synonyms	SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor
Reference Data

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