LFA3 (CD58) Mouse Monoclonal Antibody [Clone ID: MEM-63]

Specifications

Product Data
Clone Name	MEM-63
Applications	FC
Recommend Dilution	Flow Cytometry: 1:200 as starting point.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	NALM-6 human pre-B cell line
Specificity	This antibody reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts.
Formulation	Phosphate buffered saline (PBS) Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM sodium azide, approx. pH 8.0 Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD58 molecule
Database Link	Entrez Gene 965 Human UniProt ID P19256
Background	CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
Synonyms	Ag3, LFA-3
Reference Data

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