CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-226]
CAT#: SM3078APC
CD105 (ENG) mouse monoclonal antibody, clone MEM-226, APC
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CNY 4,340.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | MEM-226 |
Applications | FC |
Recommend Dilution | Flow Cytometry analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 10e6 cells in a suspension. |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA |
Specificity | The antibody MEM-226 reacts with CD105 (Endoglin), a 180 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent Label: APC State: Liquid Ig fraction Label: Cross-linked Allophycocyanin |
Purification | Size-exclusion chromatography |
Conjugation | APC |
Storage Condition | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | endoglin |
Database Link | |
Background | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Synonyms | ENG, END, HHT1, ORW, ORW1 |
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