CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-226]
CAT#: SM3078P
CD105 (ENG) mouse monoclonal antibody, clone MEM-226, Purified
Conjugation: FITC
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CNY 3,280.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | MEM-226 |
Applications | FC, IP, WB |
Recommend Dilution | Flow cytometry: Recommended dilution: 1-5 μg/ml. Western blotting: Non-reducing conditions. |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Vaccinia Virus containing human CD105 cDNA |
Specificity | The antibody reacts with CD105 (Endoglin), a 180 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography; purity: > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Gene Name | endoglin |
Database Link | |
Background | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Synonyms | ENG, END, HHT1, ORW, ORW1 |
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