CD52 Mouse Monoclonal Antibody [Clone ID: HI186]

Specifications

Product Data
Clone Name	HI186
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human tonsil.
Specificity	This antibody reacts with Human CD52 (CAMPATH-1), a 21-28 kDa glycoprotein containing a large N-linked carbohydrate moiety; mature CD52 molecule is actually much smaller (approx. 8-9 kDa). CD52 is expressed at high levels on lymphocytes, monocytes/macrophages and in male reproductive tract.
Formulation	PBS Label: APC State: Liquid purified IgG fraction Stabilizer: 0.2% (w/v) high-grade protease free BSA Preservative: 15 mM Sodium Azide Label: Conjugated with cross-linked Allophycocyanin under optimum conditions
Purification	Size-Exclusion Chromatography
Conjugation	APC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD52 molecule
Database Link	Entrez Gene 1043 Human UniProt ID P31358
Background	CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.
Synonyms	HE5, CDw52
Reference Data
Protein Families	Transmembrane

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