CD52 Mouse Monoclonal Antibody [Clone ID: HI186]

Specifications

Product Data
Clone Name	HI186
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: 2 µg/ml. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin-Embedded Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human tonsil
Specificity	This antibody Clone HI186 reacts with CD52, a 21-28 kDa glycoprotein containing a large N-linked carbohydrate moiety. Mature CD52 molecule is actually much smaller (approx. 8-9 kDa).
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD52 molecule
Database Link	Entrez Gene 1043 Human UniProt ID P31358
Background	CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.
Synonyms	HE5, CDw52
Reference Data

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