CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: HIP1]
CAT#: SM3082P
CD42b / GPIbA mouse monoclonal antibody, clone HIP1, Purified
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SM3082P is a replacement of TA320340.
CNY 3,280.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | HIP1 |
Applications | FC, FN, IHC |
Recommend Dilution | Flow Cytometry. Immunohistochemistry on Frozen Sections. Functional Application: The antibody inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets and ristocetin-induced platelet agglutination. |
Reactivity | Human, Primate |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Peripheral blood mononuclear cells of a patient suffering with CLL |
Specificity | CD42b antibody reacts with CD42b (GPIba), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIbb) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d. |
Formulation | Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4 State: Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE). |
Concentration | lot specific |
Purification | Protein A Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | glycoprotein Ib platelet alpha subunit |
Database Link | |
Background | CD42b (GPIba) composes together with GPIbb, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. |
Synonyms | Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha |
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