CD38 Mouse Monoclonal Antibody [Clone ID: HIT2]

Specifications

Product Data
Clone Name	HIT2
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human thymocytes in foetus
Specificity	This antibody reacts with CD38 (T10), a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells.
Formulation	Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions
Purification	Size-Exclusion Chromatography
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD38 molecule
Database Link	Entrez Gene 952 Human UniProt ID P28907
Background	CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
Synonyms	cADPr hydrolase 1, T10
Reference Data

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