STAT1 pSer727 Mouse Monoclonal Antibody [Clone ID: PSM1]

Specifications

Product Data
Clone Name	PSM1
Applications	IP, WB
Recommend Dilution	Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	STAT 1 peptide sequence 721-733 (Ser727 phosphorylated).
Specificity	The antibody PSM1 recognizes STAT1 (91 kDa) activated by phosphorylation at Ser727.
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified IgG fraction (> 95% by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	signal transducer and activator of transcription 1
Database Link	Entrez Gene 6772 Human UniProt ID P42224
Background	STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
Synonyms	DKFZp686B04100; ISGF-3; OTTHUMP00000205845; STAT91
Reference Data

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