DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: DR-4-02]

Specifications

Product Data
Clone Name	DR-4-02
Applications	FC, IF
Recommend Dilution	Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
Specificity	This antibody recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Formulation	Phosphate buffered saline (PBS) Label: APC State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free BSA Preservative: 15 mM Sodium Azide Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration	lot specific
Purification	The conjugate is purified by size-exclusion chromatography
Conjugation	APC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	tumor necrosis factor receptor superfamily member 10a
Database Link	Entrez Gene 8797 Human UniProt ID O00220
Background	TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Synonyms	APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.