CD44 Mouse Monoclonal Antibody [Clone ID: MEM-85]
CAT#: SM3153F
CD44 mouse monoclonal antibody, clone MEM-85, FITC
Conjugation: Unconjugated Biotin
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CNY 3,810.00
Specifications
Product Data | |
Clone Name | MEM-85 |
Applications | FC |
Recommend Dilution | Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Leukocytes of a patient suffering from LGL Type Leukaemia |
Specificity | The antibody MEM-85 reacts with both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM sodium azide Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. |
Conjugation | FITC |
Storage Condition | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | CD44 molecule (Indian blood group) |
Database Link | |
Background | CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells. |
Synonyms | LHR, MDU2, MDU3, MIC4, CDw44, Epican, ECMR-III, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, PGP-1 |
Note | HLDA IV; WS Code NL 706 HLDA VI; WS Code AS Ref.15 |
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