CXCL8 Mouse Monoclonal Antibody [Clone ID: 8M6]

Specifications

Product Data
Clone Name	8M6
Applications	ELISA, FC, FN, WB
Recommend Dilution	ELISA: 5 µg/ml. The antibody may be used in combination with SP1251 in Sandwich ELISA assays for Ovine IL-8. Western Blot. Flow Cytometry: 1/10. Membrane permeabilization is required for this application. Functional Assays: Removal of Sodium Azide is recommended prior to use in functional assays.
Reactivity	Bovine, Sheep, Canine, Ferret, Mustelid, Mink, Porcine, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Ovine IL-8
Specificity	This antibody recognizes Interleukin-8 and shows no cross-reactivity with Ovine IL-1 beta, IL-6, MCP-1 or TNF alpha. This Interleukin 8 antibody neutralises the bioactivity of Ovine IL-8.
Formulation	PBS containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	Entrez Gene 280828 Bovine UniProt ID P79255
Background	Interleukin 8, IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Synonyms	CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1
Reference Data

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