CD45 / LCA (CD45RC) Mouse Monoclonal Antibody [Clone ID: MIL15]

Specifications

Product Data
Clone Name	MIL15
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections.
Reactivity	Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Cells isolated from porcine mesenteric lymph node
Specificity	This antibody recognises the CD45RC cell surface antigen. Clone MIL15 recognises B cells in immunohistology.
Formulation	Containing 0.09% Sodium Azide State: Supernatant State: Liquid Tissue Culture Supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q6SZ85
Background	CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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