PPM1A Mouse Monoclonal Antibody [Clone ID: P6C7]

Specifications

Product Data
Clone Name	P6C7
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/250~1/1000 (1/250 as starting dilution).  Immunofluorescence/Immnunocytochemistry.  Immunohistochemistry on Paraffin Sections: 15 µg/ml.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human PP2C-alpha protein
Specificity	This antibody detects Protein Phosphatase 2C alpha (PP2C alpha).
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein phosphatase, Mg2+/Mn2+ dependent 1A
Database Link	Entrez Gene 5494 Human UniProt ID P35813
Background	Protein phosphatase 2C(PP2Cα) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNK MAPK pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2C, the prototypical member of the PPM family.
Synonyms	PPPM1A, Protein phosphatase 2C isoform alpha, PP2C-alpha, Protein phosphatase IA
Reference Data

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