GAD67 (GAD1) (+ GAD2 / GAD65) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/1000-1/10000. Immunohistochemistry on Frozen Sections: 1/200-1/5000. Recommended Positive Control: Brain.
Reactivity	Feline, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide sequence from the C-terminus of GAD
Specificity	This antibody recognises both molecular forms of Glutamic Acid Decarboxylase (GAD65 and GAD67), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
Formulation	PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. State: Purified State: Liquid purified Immunoglobulin-rich fraction.
Purification	Ammonium Sulphate Precipitation.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate decarboxylase 1
Database Link	Entrez Gene 14415 MouseEntrez Gene 24379 RatEntrez Gene 2571 Human UniProt ID Q99259
Background	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.
Synonyms	Glutamate decarboxylase 1, GAD-67
Note	Predicted Molecular Weight: 65 and 67 kDa.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus

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