IL8 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA (1/500 for detection; Use SM482 as coating antibody; It is recommended that SP1251 and any detection antibody are diluted in 10% Normal Mouse serum prior to use in ELISA).
Reactivity	Sheep
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Ovine IL-8
Specificity	Recognizes Ovine Interleukin-8 (IL-8). No cross-reactivity is seen with Ovine IL-1 beta, IL-6, MCP or TNF alpha.
Formulation	State: Serum State: Liquid Serum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P36925
Background	Interleukin 8, IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Synonyms	CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1
Reference Data

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