Von Willebrand Factor (VWF) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, FC, ID, IF, IHC
Recommend Dilution	Immunodiffusion: Neat. ELISA. Flow Cytometry. Immunofluorescence. Immunohistochemistry on Frozen Sections: The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. The use of acetone fixation is recommended for frozen sections. Recommended Positive Control: Tonsil. Does not work on paraffin sections!.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Purified Human von Willebrand factor.
Specificity	This antibody recognizes Human Willebrand factor VIII. Other species not tested.
Formulation	Glycine buffered saline pH 7.4, 0.01% Benzamidine, 0.1% EACA and 1mM EDTA State: Purified State: Liquid purified IgG fraction from Serum Preservative: 0.09% Sodium Azide
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	von Willebrand factor
Database Link	Entrez Gene 7450 Human UniProt ID P04275
Background	Von Willebrand Factor (VWF) was previously known as Factor VIII related antigenis. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).
Synonyms	vWF, von Willebrand antigen 2, von Willebrand antigen II, F8VWF, Factor VIII Related Antigen
Reference Data

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