Hamartin (TSC1) Rabbit Polyclonal Antibody

CAT#: SP2163P

Hamartin (TSC1) rabbit polyclonal antibody, Aff - Purified



Need it in bulk or conjugated?
Get a free quote

CNY 5,850.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IF, WB
Recommend Dilution Western blot (1 µg/ml, detects a band of approximately 130 kDa in mouse EL4 cell lysates).
Immunocytochemistry.
Has been reported as suitable for use in IHC on mouse EL4 cell cytospins at 2 µg/ml.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A 15 amino acid peptide located near the centre of human TSC1
Specificity This antibody recognises an epitope within the internal region of the 130 kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1).
Formulation Phosphate buffered saline, 0.02 % Sodium Azide
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Affinity chromatography
Conjugation Unconjugated
Storage Condition Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Gene Name tuberous sclerosis 1
Background Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene.
Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.
Synonyms KIAA0243, TSC, Tuberous sclerosis 1 protein
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...