Collagen I (COL1A1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections (1/10-1/20). ELISA.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Human type 1 Collagen
Specificity	This antibody recognizes Human Type 1 Collagen. It has been cross-adsorbed against Collagen types II, III, IV, V and VI. Results from ELISA demonstrate < 10% cross-reactivity with other Collagen types.
Formulation	Borate buffered saline State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: None Preservative: None
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	collagen type I alpha 1
Database Link	Entrez Gene 1277 Human UniProt ID P02452
Background	Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
Synonyms	COL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen
Reference Data
Protein Families	Druggable Genome
Protein Pathways	ECM-receptor interaction, Focal adhesion

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