CCR7 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	Immunocytochemistry: 14 µg/ml. Immunohistochemistry on Paraffin Sections: 14 µg/ml.
Reactivity	Human, Bovine, Bat, Equine, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic 17 amino acid peptide from C-terminus of human CCR7
Specificity	Reacts with C-terminus of CCR7 (family: GPCR, subfamily: Chemokine).
Formulation	PBS containing 0.09% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Peptide Immunogen Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine receptor 7
Database Link	Entrez Gene 1236 Human UniProt ID P32248
Background	CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. This receptor is particularly expressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.
Synonyms	C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EVI1, BLR2
Reference Data

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