Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) Rabbit Polyclonal Antibody

CAT#: SP4124P

Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) rabbit polyclonal antibody, Aff - Purified



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CNY 5,654.00


货期*
5周

规格
    • 50 ug

Cited in 1 publication.

Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution Immunocytochemistry.
Immunohistochemistry on Paraffin Sections: 4 - 11 µg/ml.
Western Blot.
Reactivity Canine, Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB
Specificity Detects N-terminal extracellular domain of Endothelin B Receptor (Family: GPCR; Subfamily: Endothelin).
Formulation PBS containing 0.09% Sodium Azide as preservative
State: Aff - Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Peptide Immunogen Affinity Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer.
Avoid repeated freezing and thawing.
Gene Name endothelin receptor type B
Background The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.
The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel.
Synonyms ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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