Endothelin B Receptor (EDNRB) (N-term, Extracel. Dom.) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 4 - 11 µg/ml. Western Blot.
Reactivity	Canine, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB
Specificity	Detects N-terminal extracellular domain of Endothelin B Receptor (Family: GPCR; Subfamily: Endothelin).
Formulation	PBS containing 0.09% Sodium Azide as preservative State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Peptide Immunogen Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer. Avoid repeated freezing and thawing.
Gene Name	endothelin receptor type B
Database Link	Entrez Gene 1910 Human UniProt ID P24530
Background	The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel.
Synonyms	ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
Reference Data

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