MEK4 (MAP2K4) Rabbit Polyclonal Antibody
CAT#: TA300116
Rabbit Polyclonal Antibody against MAP2K4
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CNY 6,160.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 1:1000, IHC: 1:10~50 |
Reactivity | Human, Mouse, Xenopus |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | This MEKK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEKK4(MAP2K4). |
Formulation | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | mitogen-activated protein kinase kinase 4 |
Database Link | |
Background | MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. |
Synonyms | JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway |
Documents
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