S100A12 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:500, Western Blot: 1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length human S100A12 protein [Swiss-Prot# P80511] expressed in E. coli.
Formulation	0.1% sodium azide
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	S100 calcium binding protein A12
Database Link	NP_005612 Entrez Gene 6283 Human UniProt ID P80511
Background	S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
Synonyms	CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6
Reference Data

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