DLX4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, IHC, IP, WB
Recommend Dilution	Immunohistochemistry: 1:50-1:100, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:50-1:100, Immunohistochemistry-Frozen, Chromatin Immunoprecipitation (ChIP)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made specifically to the human BP1 protein sequence (between residues 1-60).There is no homology with the peptide sequences used for immunogen of this antibody and the DLX4 or DLX7 proteins.
Formulation	Tris-citrate/phosphate, pH 7-8, 0.1% sodium Azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	26 kDa
Gene Name	distal-less homeobox 4
Database Link	NP_612138 Entrez Gene 1748 Human UniProt ID Q92988
Background	DLX (Distal-less) genes are essential for early development. BP1 (beta protein 1) is a homeodomain-containing isoform of DLX4. Strong BP1 expression is seen in placenta and kidney tissue, with no expression found in any other tissue (1). This protein has been shown to be activated in 80% of invasive ductal breast tumors and is associated with breast cancer progression ( 2, 3). It is also expressed in the bone marrows of 63% of acute myeloid leukemia (AML) patients (4). In addition, BP1 plays a role in globin gene regulation by repressing the beta- globin gene (1).
Synonyms	BP1; DLX7; DLX8; DLX9; OFC15
Reference Data
Protein Families	Transcription Factors

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